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Sleep duration and myocardial infarction

Daghlas, I., Dashti, H.S., Lane, J., Aragam, K.G., Rutter, M.K., Saxena, R. and Vetter, C. (2019). Sleep Duration and Myocardial Infarction. Journal of the American College of Cardiology, [online] 74(10), pp.1304–1314. Available at: https://www.sciencedirect.com/science/article/pii/S0735109719359492.

Abstract: Observational studies suggest associations between extremes of sleep duration and myocardial infarction (MI), but the causal contribution of sleep to MI and its potential to mitigate genetic predisposition to coronary disease is unclear. This study sought to investigate associations between sleep duration and incident MI, accounting for joint effects with other sleep traits and genetic risk of coronary artery disease, and to assess causality using Mendelian randomization (MR).